Four Key Symptoms of Rapidly-Mutating ‘Pirola’ Covid Variant as More Cases Found in UK


Public health officials in the UK have recently identified an emerging concern with the rapidly-mutating Covid variant known as Pirola, labeled as variant BA.2.86. This variant, characterized by a high number of mutations, has raised alarms among scientists due to its potential to evade immunity from previous infections or vaccinations. As cases of Pirola continue to emerge, experts have highlighted four common symptoms associated with this variant, shedding light on what individuals should watch out for.

The Emergence of Pirola:

On August 16, Public Health Scotland (PHS) confirmed the presence of Pirola through a PCR test. Less than two weeks later, on August 29, this variant was detected in wastewater in another NHS board area. Pirola has already been observed in England, Sweden, Canada, and the United States, earning its reputation as the “most striking variant since Omicron.”

Common Symptoms of Pirola:

Dr. Chris Papadopoulos, Principal Lecturer in Public Health at the University of Bedfordshire, has identified four key symptoms associated with Pirola, which align with typical Covid symptoms:

  • Sore throat
  • Runny or blocked nose
  • Cough (with or without phlegm)
  • Headaches

Dr. Papadopoulos emphasizes that, at present, there is insufficient data to definitively distinguish Pirola’s symptoms from those of other Covid variants. Therefore, it remains unclear if Pirola causes unique symptoms distinct from other variants. He urges individuals experiencing any of these symptoms to seek testing, as Pirola is potentially more transmissible and severe due to the spike protein’s high mutation rate.

Ongoing Investigation:

While Pirola’s characteristics continue to be examined, the UK Health Security Agency has convened a technical group meeting to assess variant BA.2.86. Researchers stress the importance of further analysis, including genomic sequencing and laboratory studies, to draw definitive conclusions about this variant.

Vaccination Strategy Adjustment:

In response to the emergence of the Pirola variant, Scotland has expedited its winter vaccination program. Originally scheduled for mid-October, the vaccination rollout for care home residents, those over 75, and clinically vulnerable individuals has been moved up to September 4. This proactive measure aims to protect the most vulnerable population segments.

Cautious Approach:

Public Health Scotland acknowledges that the accuracy of detecting specific variants in wastewater can vary, underscoring the need for caution when interpreting genomic wastewater analyses. Dr. Nick Phin, Director of Public Health Science at PHS, emphasizes their commitment to safeguarding public health this winter and protecting those at the highest risk of illness.


While scientists continue their efforts to understand variant BA.2.86 (Pirola) better, public health authorities in the UK are taking proactive steps to mitigate its potential impact. With the early adjustment of the vaccination program and ongoing research, health officials aim to ensure the safety and well-being of the population in the face of this emerging Covid variant.

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